Kuyezetsa mankhwala a chotupa kuti afufuze
Kuyeza mankhwala a chotupa, komwe kumadziwikanso kuti anti-cancer drug screening kapena kuyezetsa mankhwala a khansa, kumatanthawuza njira yowunika mankhwala osiyanasiyana kuti adziwe omwe amatha kuchiza zotupa.Kuyezetsa uku kumachitidwa kuti apeze njira zothandizira odwala khansa.Imathandiza kwambiri pakupanga mankhwala atsopano komanso kupititsa patsogolo chithandizo chomwe chilipo kale.
Cholinga chachikulu chowunika mankhwala a chotupa ndikuzindikira mankhwala omwe amatha kuletsa kukula kapena kupha maselo a khansa ndikusunga maselo athanzi.Njira imeneyi, yomwe imadziwika kuti targeted therapy, ikufuna kupititsa patsogolo chithandizo chamankhwala ndikuchepetsa zotsatira zake.Kuwunika kumaphatikizapo kuyika maselo a khansa, omwe amatengedwa kuchokera ku zotupa kupita ku mankhwala osiyanasiyana kuti adziwe momwe angagwiritsire ntchito kupha maselo a khansa.
Njira zosiyanasiyana zimagwiritsidwa ntchito poyesa mankhwala a chotupa, monga kuwunika kwapamwamba, komwe kumalola kuyesa mwachangu masauzande azinthu.Njirayi imathandizira ochita kafukufuku kuzindikira omwe akulonjeza kuti atha kuwunikanso momwe amathandizira, chitetezo chawo, komanso momwe angagwiritsire ntchito kuchipatala.
MingCeler imapereka ntchito zambiri zaukadaulo wapamwamba kwambiri pakuwunika ndi kutsimikizira mankhwala a oncology, kuphatikiza chizindikiritso ndi kutsimikizira, kuyesa kwa ma cell a vivo ndikuwunika, mu vivo chotupa chopanga, mu vivo pharmacology, pharmacokinetics, pharmacodynamic ndi kuwunika koyambira kwa toxicology.
Kutengera zosowa za makasitomala athu, titha kupereka maphunziro ozama amakanika.
Chizindikiro cha chotupa ndi kutsimikizira
-Kutulutsa kwapang'onopang'ono kapena kuchulukirachulukira kwa majini omwe amatsata m'maselo opangidwa ndi ma genetic
-Mu vivo kugogoda kapena kufotokoza mopambanitsa kwa majini omwe mukufuna mumitundu ya mbewa
-Mu vivo magwiridwe antchito kuphatikiza kukula kwa chotupa, metastasis, etc.·
Chotupa chitsanzo
· In situ xenograft
·Majakisoni olowera m'mitsempha
· khansa ya m'mapapo ya metastatic
·Nyero ya ndulu yachiwindi ya metastasis
·Makoswe opangidwa mwachibadwa
Kuyesa kwa biochemical ndi ma cell level
- Kupitilira 260 STR-yovomerezeka ya Humanized tumor cell mizere yomwe imatha kuyimira pafupifupi mitundu yonse ya chotupa
- Kuyesa kwa ma cell ndi kuyesa koyambirira kwa ma cell
- Kuyeza kwa Metabolomics
- Compound Screening
- Kusankhidwa kwa mizere ya cell yovuta komanso yololera
