Selo limatchedwa kuti homozygous kwa jini inayake pamene ma alleles ofanana a jini amapezeka pa ma chromosomes onse.
Mitundu ya mbewa yopangidwa ndi anthu ili ndi ntchito zambiri pazofufuza za Edzi, khansa, matenda opatsirana, ndi matenda amagazi.
Knock-in (KI) ndi njira yomwe imagwiritsa ntchito kuphatikizika kofanana kwa majini kusamutsa jini yogwira ntchito mosiyanasiyana mu cell ndi ma genome, ndikuwonetsa bwino mu selo pambuyo pophatikizanso jini.
Conditional Knock-out (CKO) ndi ukadaulo wodziwikiratu wa jini womwe umakwaniritsidwa ndi kachitidwe kophatikizanso komweko.
Mwa kupemphaTurboMice™tekinoloje, titha kuyang'ana mwachindunji ma cell a embryonic tsinde pambuyo pa kusintha kwa jini m'masiku 3-5, kenako kupanga selo la tetraploid, ndikupeza mbewa zosinthidwa ndi ma homozygous m'miyezi 3-5 pambuyo pobadwa ndi mbewa za amayi, zomwe zimatha kupulumutsa chaka chimodzi. kwa makasitomala athu.
TurboMice™Ukadaulo umathandizira kukonza ma jini olondola a zidutswa zazitali kupitilira 20kb, potero kumathandizira kupanga mwachangu mitundu yovuta monga humanization, conditional knockout (CKO), ndi big fragment knock-in (KI).