Polimbana ndi mliriwu koyambirira kwa 2020, m'masiku 35 okha, mtundu wa mbewa wa ACE2 udakhazikitsidwa, ndipo wofufuza Guangming Wu ndi anzawo aku Center for Cell Fate and Lineage Research (CCLA) ku Bio-Island Laboratories adachita bwino. Kupambana kwakukulu pogwiritsa ntchito ukadaulo wa stem cell kupanga "nkhondo yolimbana ndi Chibayo Chatsopano cha Coronary".Chozizwitsa cha liwiro mu kuukira mwadzidzidzi.
Kuyesedwa kwadzidzidzi
Mu Ogasiti 2019, Wu Guangming, wofufuza kwanthawi yayitali pankhani yakukula kwa embryonic, adabwerera ku Guangzhou kuchokera ku Germany kuti akalowe nawo gulu loyamba la "Chigawo cha Guangdong kuti apange gulu losungirako zasayansi" la Bio-Island Laboratory, lomwe ndi Guangzhou Guangdong Laboratory of Regenerative Medicine ndi Health.
Chimene samayembekezera chinali chakuti sipanatenge nthawi kuti akumane ndi mayeso osayembekezeka a mliri watsopano wa chibayo cha korona.
"Munda wofufuza womwe ndikuchita nawo ulibe kanthu kochita ndi matenda opatsirana, koma poyang'anizana ndi mliri womwe ukubwera, atamva kuti dipatimenti ya Sayansi ndi Zamakono ya Guangdong Provincial idakhazikitsa ntchito yapadera yofufuza mwadzidzidzi pa korona watsopano. mliri wa chibayo, ndidadzifunsa kuti ndingachite chiyani kuti ndithane ndi mliriwu dziko lonse likugwira ntchito limodzi. ”
Kupyolera mu kumvetsetsa, Wu Guangming adapeza kuti nyama zokhala ndi anthu zimafunikira mwachangu kuti adziwe komanso kuchiza coronavirus yatsopano komanso kuwongolera kwake kwanthawi yayitali.Zomwe zimatchedwa humanized nyama chitsanzo ndi kupanga nyama (nyani, mbewa, etc.) ndi makhalidwe ena a minyewa ya anthu, ziwalo, ndi maselo kudzera jini kusintha ndi njira zina kumanga zitsanzo matenda, kuphunzira njira tizilombo matenda a anthu ndi kupeza. njira zabwino zothandizira.
Kuukiraku kunatha m'masiku 35
Wu Guangming adauza mtolankhaniyo kuti panthawiyo panali ma cell a in vitro okha ndipo anthu ambiri anali ndi nkhawa.Anakhala ndi zaka zambiri pa kafukufuku wa zinyama za transgenic komanso anali wabwino pa tetraploid compensation technology.Limodzi mwa malingaliro ake ofufuza kalelo linali kuphatikizira umisiri wa embryonic stem cell ndi ukadaulo wa embryonic tetraploid compensation pamodzi kuti akhazikitse zitsanzo za mbewa zaumunthu, ndipo zinali zolimbikitsa kuti Center for Cell Fate ndi Genealogy Research ku Bio Island Laboratories ndiye inali ndiukadaulo wotsogola wa cell. , ndipo zinkawoneka kuti mikhalidwe yonse yakunja inali yakucha.
Kuganiza ndi chinthu chimodzi, kuchita ndi chinanso.
Ndizovuta bwanji kupanga mbewa yogwiritsiridwa ntchito?Pazochita zanthawi zonse, zingatenge miyezi isanu ndi umodzi ndikudutsa njira zambiri zoyeserera ndi zolakwika.Koma mukukumana ndi mliri wadzidzidzi, munthu amayenera kuthamanga motsutsana ndi nthawi ndikukhazikika pamapu.
Gululi lidakhazikitsidwa mwangozi chifukwa anthu ambiri anali atapita kale kwawo ku Chaka Chatsopano cha China.Pomaliza, anthu asanu ndi atatu omwe adatsalira ku Guangzhou adapezeka pansi pa Center for Cell Fate ndi Genealogy Research bungwe kuti apange gulu lachitsanzo lachitsanzo laumunthu.
Kuchokera pamapangidwe a protocol yoyeserera pa Januware 31 mpaka kubadwa kwa m'badwo woyamba wa mbewa zaumunthu pa Marichi 6, gululo lidakwaniritsa chozizwitsa ichi cha kafukufuku wasayansi m'masiku 35 okha.Ukadaulo wokhazikika umafunikira kusakaniza ma cell a mbewa ndi miluza kuti apeze mbewa za chimeric, ndipo pokhapokha ngati ma cell a tsinde amasiyana m'maselo a majeremusi ndiyeno kukwatirana ndi mbewa zina kuti apereke majeremusi osinthidwa ku m'badwo wotsatira wa mbewa angaonedwe kuti ndi opambana.Makoswe opangidwa ndi anthu ochokera ku CCLA adabadwa kuti apeze mbewa zomwe akufuna kugunda nthawi imodzi, kupeza nthawi yofunikira ndikupulumutsa anthu ogwira ntchito ndi zida zothana ndi mliri.
Wu Guangming ali pantchito Chithunzi/choperekedwa ndi wofunsidwayo
Onse ntchito owonjezera
Wu Guangming adavomereza kuti pachiyambi, palibe mtima wa munthu womwe unali ndi pansi, ndipo teknoloji ya tetraploid yokha inali yovuta kwambiri, ndi kupambana kwapakati pa 2%.
Pa nthawiyo, anthu onse anali odzipereka kwambiri pa kafukufukuyu, mosasamala kanthu za usana ndi usiku, popanda masiku ogwira ntchito komanso Loweruka ndi Lamlungu.Tsiku lililonse nthawi ya 3:00 kapena 4:00 m’maŵa, anthu a m’gululo ankakambirana mmene tsikulo likuyendera;anacheza mpaka mbandakucha ndipo nthawi yomweyo anabwerera ku tsiku lina la kafukufuku.
Monga mtsogoleri waukadaulo wa gulu lofufuza, Wu Guangming akuyenera kulinganiza mbali ziwiri za ntchito - kusintha kwa majini ndi chikhalidwe cha mwana wosabadwayo - ndipo amayenera kutsatira njira iliyonse yoyeserera ndikuthana ndi mavuto munthawi yake, zomwe zimadetsa nkhawa kwambiri kuposa momwe munthu angathere. lingalirani.
Panthawiyo, chifukwa cha tchuthi cha Chikondwerero cha Spring ndi mliri, ma reagents onse ofunikira anali atatha, ndipo tinkayenera kupeza anthu kulikonse kuti tibwereke.Ntchito ya tsiku ndi tsiku inali kuyesa, kuyesa, kutumiza zitsanzo ndikuyang'ana ma reagents.
Pofuna kufulumizitsa nthawi, gulu lofufuzira linathyola chikhalidwe choyesera, pamene kukonzekera koyambirira kwa sitepe iliyonse yoyesera.Koma izi zikutanthauzanso kuti ngati china chake sichikuyenda bwino m'masitepe am'mbuyomu, masitepe otsatirawa amakonzedwa pachabe.
Komabe, kuyesa kwachilengedwenso ndi njira yomwe imafunikira kuyesa kosalekeza ndikulakwitsa.
Wu Guangming amakumbukirabe kuti kamodzi, vekitala ya in vitro idagwiritsidwa ntchito kuyika mumayendedwe a DNA, koma sizinagwire ntchito, chifukwa chake adayenera kusintha mawonekedwe a reagent ndi magawo ena mobwerezabwereza ndikuzichita mobwerezabwereza mpaka ntchito.
Ntchitoyi inali yopanikiza kwambiri moti aliyense anali atatopa kwambiri, ena anali ndi matuza m’kamwa, ndipo ena anali otopa kwambiri moti ankangogona pansi kuti alankhule chifukwa ankalephera kuyimirira.
Kuti apambane, Wu Guangming, komabe, adanenanso kuti anali ndi mwayi kukumana ndi gulu la osewera nawo, ndipo zinali zabwino kumaliza ntchito yomanga mbewa munthawi yochepa.
Ndikufunabe kuwongolera
Pa Marichi 6, mbewa za 17 za m'badwo woyamba zidabadwa bwino.Komabe, izi zitha kufotokozedwa ngati gawo loyamba pomaliza ntchitoyo, yomwe idatsatiridwa mwachangu ndi njira yotsimikizika yotsimikizika komanso kutumiza mbewa zamunthu ku labu ya P3 kuti akayezetse bwino kachilomboka.
Komabe, Wu Guangming adaganiziranso zakusintha kwina kwa mbewa.
Adauza atolankhani kuti 80% ya odwala omwe ali ndi COVID-19 ndi asymptomatic kapena akudwala pang'ono, kutanthauza kuti atha kudalira chitetezo chawo kuti achire, pomwe ena 20% odwala amakhala ndi matenda oopsa, makamaka okalamba kapena omwe ali ndi matenda oyambitsa matenda. .Choncho, kuti agwiritse ntchito molondola komanso moyenera zitsanzo za mbewa pa kafukufuku wa matenda, mankhwala, ndi katemera, gululi likuyang'ana mbewa zaumunthu kuphatikizapo kukalamba msanga, matenda a shuga, matenda oopsa, ndi zina zomwe zimayambitsa matenda kuti akhazikitse chitsanzo cha mbewa zoopsa.
Poyang'ana mmbuyo pa ntchito yaikulu, Wu Guangming adanena kuti amanyadira gulu loterolo, pomwe aliyense amamvetsetsa kufunika kwa zomwe akuchita, anali ndi chidziwitso chapamwamba, ndipo adagwira ntchito mwakhama kuti akwaniritse zotsatirazi.
Maulalo ankhani zofananira:"Guangdong War Epidemic to Honor Heroes" Gulu la Wu Guangming: masiku 35 kuti akhazikitse mtundu wa mbewa wa ACE2 (baidu.com)
Nthawi yotumiza: Aug-02-2023